| General Information |
| MoonProt ID | 47 |
| First appeared in release | 1.0 |
| Name(s) | fructose-1,6-bisphosphate aldolase
Fructose-bisphosphate aldolase
Gene Name: fba |
| UniProt ID | F0N9L0 (F0N9L0_NEIMN), Unreviewed |
| GO terms | GO:0005975 carbohydrate metabolic process
GO:0006096 glycolysis
GO:0003824 catalytic activity
GO:0004332 fructose-bisphosphate aldolase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0016832 aldehyde-lyase activity |
| Organisms for which functions have been demonstrated | Neisseria meningitidis (Gram negative bacterium, causes meningitis) |
| Sequence length | 354 |
| FASTA sequence | >gi|254804307|ref|YP_003082528.1| fructose-1,6-bisphosphate aldolase [Neisseria meningitidis alpha14]
MALVSMRQLLDHAAENSYGLPAFNVNNLEQMRAIMEAADQVNAPVIVQASAGARKYAGAPFLRHLILAAVEEFPHIPVVMHQDHGASPDVCQRSIQLGFSSVMMDGSLMEDGKTPSSYEYNVNATRTVVNFSHACGVSVEGEIGVLGNLETGEAGEEDGVGAVGKLSHDQMLTSVEDAVRFVKDTGVDALAIAVGTSHGAYKFTRPPTGDVLRIDRIKEIHQALPNTHIVMHGSSSVPQEWLKVINEYGGNIGETYGVPVEEIVEGIKHGVRKVNIDTDLRLASTGAVRRYLAENPSDFDPRKYLSKTIEAMKQICLDRYLAFGCEGQAGKIKPVSLEKMANRYAKGELNQIVK |
| Structure Information |
| PDB ID | 5U4N |
| Quaternary structure | |
| SCOP | TIM beta/alpha-barrel |
| CATH | 3.20.20.70 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | fructose-1,6-bisphosphate aldolase, enzyme |
| References for function | |
| E.C. number | 4.1.2.13 |
| Location of functional site(s) | |
| Cellular location of function | cytosol |
| Comments | |
| Function 2 |
| Function description | adhesin to human cells |
| References for function | Tunio SA, Oldfield NJ, Berry A, AlaAldeen DA, Wooldridge KG, Turner DP. The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis: surface localization and role in host cell adhesion.
Mol Microbiol. 2010 May;76(3):605-15. doi: 10.1111/j.1365-2958.2010.07098.x. Epub 2010 Feb 28.
PMID: 20199602 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |