Protein Information

General Information
MoonProt ID479
First appeared in release3.0
Name(s)riboflavin kinase/regulator (RbkR)
UniProt IDNA
GO termsNA
Organisms for which functions have been demonstratedPyrobaculum yellowstonensis WP30
Sequence length210 aa
FASTA sequence>AKT35049.1 CTP-dependent riboflavin kinase [Pyrobaculum sp. WP30] MECVDRRLVGDLLALSRVEGLPVAEAAGRLCMTRQGLYKILRSLRERGYVEEGPVVKLSQRGRDILSAALRELLSYFNIASIRVVGVVVSGLGEGAFYISLEGYRRVMEELLGFVPYPGTLNVKLDPQSLPYRRYLESLPGILIPGFTNGMRTYGAVKAFRARIRGVEGAVVMPERTHHPTDVIEVVASVKLRDVLGLRDGDKVEIEIYL
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Predictionno TM helices # AKT35049.1 Number of predicted TMHs: 0 # AKT35049.1 Exp number of AAs in TMHs: 9.79469 # AKT35049.1 Exp number, first 60 AAs: 0.01017 # AKT35049.1 Total prob of N-in: 0.29912 AKT35049.1 TMHMM2.0 outside 1 210
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on MFDp2 webserver. AKT35049_1_CTP_dependent is 210 residues long, with 0 residues (0.00 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments.
Connections to Disease
OMIM ID
Function 1
Function descriptionCTP-dependent riboflavin kinase
References for functionRodionova IA, Vetting MW, Li X, Almo SC, Osterman AL, Rodionov DA. A novel bifunctional transcriptional regulator of riboflavin metabolism in Archaea. Nucleic Acids Res. 2017 Apr 20;45(7):3785-3799. doi: 10.1093/nar/gkw1331. PMID: 28073944; PMCID: PMC5397151.
E.C. number
Location of functional site(s)
Cellular location of function
CommentsRbkR proteins are composedof the riboflavin kinase domain and a DNA-bindingwinged helix-turn-helix-like domain
Function 2
Function descriptionDNA binding protein. Transcriptional regulator of riboflavin metabolism, PF12802 archael.
References for functionRodionova IA, Vetting MW, Li X, Almo SC, Osterman AL, Rodionov DA. A novel bifunctional transcriptional regulator of riboflavin metabolism in Archaea. Nucleic Acids Res. 2017 Apr 20;45(7):3785-3799. doi: 10.1093/nar/gkw1331. PMID: 28073944; PMCID: PMC5397151.
E.C. number
Location of functional site(s)
Cellular location of function
Comments