| General Information |
| MoonProt ID | 484 |
| First appeared in release | 4.0 |
| Name(s) | Malate synthase |
| UniProt ID | G8BCH3 |
| GO terms | "GO:0003824 catalytic activity
GO:0004474 malate synthase activity
GO:0016740 transferase activity
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix" |
| Organisms for which functions have been demonstrated | Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis) |
| Sequence length | 551.0 |
| FASTA sequence | >tr|G8BCH3|G8BCH3_CANPC Malate synthase OS=Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) OX=578454 GN=MLS1 PE=3 SV=1 MSGPFPTVAEKIKGVQVLGPIPDNAKHIFSQEALAFVATLHRGFEKTRQQLLNNRKEEQK RRDQGYLPNFLPETEHIRNDPTWTGPPLAPGLIDRRCEITGPTDRKMVINALNSNVATYM ADFEDSLTPAWRNLVDGQVNLYDGVRRNLSYETNGKKYALNLKEGRHIPTLIVRPRGWHL TEKHVLVDGQPVSGGIFDFAIYFFNNAKETLARGFGPYFYLPKMEHHLEAKLWNDIFNYS QDYIGIPRGTIRGSVLIETIPAVFQMDEIIYQLREHSAGLNCGRWDYIFSYIKCLRNFPE FILPDRSQVTMAAPFMSSYVKLLVHTTHKRKVHALGGMAAQIPIKDDEERNRKALENVTK DKLREVSLGCDSCWVAHPALVPVVLKVFNEHMKGPNQIDLPPKEPFKPVTQRDLLSPFVP GGVITEGGIRANIIIGISYIEAWLRNVGCVPINYLMEDAATAEVSRTQIWQWVTHGAKTN TGKVITKDYVKQLLDEEYAKLTKNAKPGNKFKQAFAYFAPEALGERYSDFVTTLIYDDIT TVGRAIPGEKL |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | not in DisProt |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-7), middle region (aa 49-85, 398-404), and C terminus (aa 547-551) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, malate synthase |
| References for function | Kozik A, Karkowska-Kuleta J, Zajac D, Bochenska O, Kedracka-Krok S, Jankowska U, Rapala-Kozik M. Fibronectin-, vitronectin- and laminin-binding proteins at the cell walls of Candida parapsilosis and Candida tropicalis pathogenic yeasts. BMC Microbiol. 2015 Oct 5;15:197. doi: 10.1186/s12866-015-0531-4. PMID: 26438063; PMCID: PMC4595241. |
| E.C. number | EC:2.3.3.9 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds fibronectin |
| References for function | Kozik A, Karkowska-Kuleta J, Zajac D, Bochenska O, Kedracka-Krok S, Jankowska U, Rapala-Kozik M. Fibronectin-, vitronectin- and laminin-binding proteins at the cell walls of Candida parapsilosis and Candida tropicalis pathogenic yeasts. BMC Microbiol. 2015 Oct 5;15:197. doi: 10.1186/s12866-015-0531-4. PMID: 26438063; PMCID: PMC4595241. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |