Protein Information

General Information
MoonProt ID498
First appeared in release3.0
Name(s)Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic Gene: GAPA Recommended name: Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic (EC:1.2.1.13) Alternative name(s): NADP-dependent glyceraldehydephosphate dehydrogenase subunit A
UniProt IDP50362 (G3PA_CHLRE)
GO termsGO:0009507 chloroplast GO:0055114 oxidation-reduction process GO:0019253 reductive pentose-phosphate cycle GO:0009536 plastid GO:0016491 oxidoreductase activity GO:0047100 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity GO:0019253 reductive pentose-phosphate cycle
Organisms for which functions have been demonstratedChlamydomonas reinhardtii (Chlamydomonas smithii)
Sequence length374 amino acids
FASTA sequence>sp|P50362|G3PA_CHLRE Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic OS=Chlamydomonas reinhardtii OX=3055 GN=GAPA PE=1 SV=1 MAAMMQKSAFTGSAVSSKSGVRAKAARAVVDVRAEKKIRVAINGFGRIGRNFLRCWHGRQNTLLDVVAINDSGGVKQASHLLKYDSTLGTFAADVKIVDDSHISVDGKQIKIVSSRDPLQLPWKEMNIDLVIEGTGVFIDKVGAGKHIQAGASKVLITAPAKDKDIPTFVVGVNEGDYKHEYPIISNASCTTNCLAPFVKVLEQKFGIVKGTMTTTHSYTGDQRLLDASHRDLRRARAAALNIVPTTTGAAKAVSLVLPSLKGKLNGIALRVPTPTVSVVDLVVQVEKKTFAEEVNAAFREAANGPMKGVLHVEDAPLVSIDFKCTDQSTSIDASLTMVMGDDMVKVVAWYDNEWGYSQRVVDLAEVTAKKWVA
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Predictionno TM helices # sp|P50362|G3PA_CHLRE Number of predicted TMHs: 0 # sp|P50362|G3PA_CHLRE Exp number of AAs in TMHs: 0.26817 # sp|P50362|G3PA_CHLRE Exp number, first 60 AAs: 0 # sp|P50362|G3PA_CHLRE Total prob of N-in: 0.02629 sp|P50362|G3PA_CHLRE TMHMM2.0 outside 1 374
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on the MFDp2 webserver. spP50362G3PA_CHLRE_Glyce is 374 residues long, with 15 residues (4.01 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments. Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 1 and 15 in the sequence. The segment is 15 residues long (4.01 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptionglyceraldehyde-3-phosphate dehydrogenase
References for functionGraciet E, Lebreton S, Camadro JM, Gontero B. Characterization of native and recombinant A4 glyceraldehyde 3-phosphate dehydrogenase. Kinetic evidence for confromation changes upon association with the small protein CP12. Eur J Biochem. 2003 Jan;270(1):129-36. doi: 10.1046/j.1432-1033.2003.03372.x. PMID: 12492483.
E.C. number1.2.1.13
Location of functional site(s)
Cellular location of functionchloroplast
Comments
Function 2
Function descriptionthiol-disulfide exchange with CP12
References for functionErales J, Lorenzi M, Lebrun R, Fournel A, Etienne E, Courcelle C, Guigliarelli B, Gontero B, Belle V. A new function of GAPDH from Chlamydomonas reinhardtii: a thiol-disulfide exchange reaction with CP12. Biochemistry. 2009 Jun 30;48(25):6034-40. doi: 10.1021/bi900569h. PMID: 19456123.
E.C. number
Location of functional site(s)
Cellular location of functionchloroplast
Comments