General Information |
MoonProt ID | 498 |
First appeared in release | 3.0 |
Name(s) | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic
Gene: GAPA
Recommended name:
Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic (EC:1.2.1.13)
Alternative name(s):
NADP-dependent glyceraldehydephosphate dehydrogenase subunit A |
UniProt ID | P50362 (G3PA_CHLRE) |
GO terms | GO:0009507 chloroplast
GO:0055114 oxidation-reduction process
GO:0019253 reductive pentose-phosphate cycle
GO:0009536 plastid
GO:0016491 oxidoreductase activity
GO:0047100 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity
GO:0019253 reductive pentose-phosphate cycle |
Organisms for which functions have been demonstrated | Chlamydomonas reinhardtii (Chlamydomonas smithii) |
Sequence length | 374 amino acids |
FASTA sequence | >sp|P50362|G3PA_CHLRE Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic OS=Chlamydomonas reinhardtii OX=3055 GN=GAPA PE=1 SV=1
MAAMMQKSAFTGSAVSSKSGVRAKAARAVVDVRAEKKIRVAINGFGRIGRNFLRCWHGRQNTLLDVVAINDSGGVKQASHLLKYDSTLGTFAADVKIVDDSHISVDGKQIKIVSSRDPLQLPWKEMNIDLVIEGTGVFIDKVGAGKHIQAGASKVLITAPAKDKDIPTFVVGVNEGDYKHEYPIISNASCTTNCLAPFVKVLEQKFGIVKGTMTTTHSYTGDQRLLDASHRDLRRARAAALNIVPTTTGAAKAVSLVLPSLKGKLNGIALRVPTPTVSVVDLVVQVEKKTFAEEVNAAFREAANGPMKGVLHVEDAPLVSIDFKCTDQSTSIDASLTMVMGDDMVKVVAWYDNEWGYSQRVVDLAEVTAKKWVA |
Structure Information |
PDB ID | NA |
Quaternary structure | NA |
SCOP | |
CATH | |
TM Helix Prediction | no TM helices
# sp|P50362|G3PA_CHLRE Number of predicted TMHs: 0
# sp|P50362|G3PA_CHLRE Exp number of AAs in TMHs: 0.26817
# sp|P50362|G3PA_CHLRE Exp number, first 60 AAs: 0
# sp|P50362|G3PA_CHLRE Total prob of N-in: 0.02629
sp|P50362|G3PA_CHLRE TMHMM2.0 outside 1 374 |
DisProt Annotation | |
Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
spP50362G3PA_CHLRE_Glyce is 374 residues long, with 15 residues (4.01 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment
Segment is located between positions 1 and 15 in the sequence.
The segment is 15 residues long (4.01 % of the total sequence length). |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | glyceraldehyde-3-phosphate dehydrogenase |
References for function | Graciet E, Lebreton S, Camadro JM, Gontero B. Characterization of native and recombinant A4 glyceraldehyde 3-phosphate dehydrogenase. Kinetic evidence for confromation changes upon association with the small protein CP12. Eur J Biochem. 2003 Jan;270(1):129-36. doi: 10.1046/j.1432-1033.2003.03372.x. PMID: 12492483. |
E.C. number | 1.2.1.13 |
Location of functional site(s) | |
Cellular location of function | chloroplast |
Comments | |
Function 2 |
Function description | thiol-disulfide exchange with CP12 |
References for function | Erales J, Lorenzi M, Lebrun R, Fournel A, Etienne E, Courcelle C, Guigliarelli B, Gontero B, Belle V. A new function of GAPDH from Chlamydomonas reinhardtii: a thiol-disulfide exchange reaction with CP12. Biochemistry. 2009 Jun 30;48(25):6034-40. doi: 10.1021/bi900569h. PMID: 19456123. |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | chloroplast |
Comments | |