Protein Information

General Information
MoonProt ID502
First appeared in release3.0
Name(s)U4/U6 small nuclear ribonucleoprotein Prp31
UniProt IDQ8WWY3 (PRP31_HUMAN)
GO termsGO:0000244 spliceosomal tri-snRNP complex assembly GO:0000398 mRNA splicing, via spliceosome GO:0003723 RNA binding GO:0005515 protein binding GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005681 spliceosomal complex GO:0005684 U2-type spliceosomal complex GO:0005687 U4 snRNP GO:0005690 U4atac snRNP GO:0006397 mRNA processing GO:0008380 RNA splicing GO:0015030 Cajal body GO:0016607 nuclear speck GO:0030621 U4 snRNA binding GO:0030622 U4atac snRNA binding GO:0042802 identical protein binding GO:0043021 ribonucleoprotein complex binding GO:0046540 U4/U6 x U5 tri-snRNP complex GO:0048254 snoRNA localization GO:0070990 snRNP binding GO:0071005 U2-type precatalytic spliceosome GO:0071011 precatalytic spliceosome GO:0071166 ribonucleoprotein complex localization GO:0071339 MLL1 complex GO:0097526 spliceosomal tri-snRNP complex
Organisms for which functions have been demonstratedHomo sapiens (human, a mammal)
Sequence length499 amino acids
FASTA sequence>sp|Q8WWY3|PRP31_HUMAN U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2 MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKTIAKLWDSKMF AEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSK RFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLS EEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTN LSKMPACNIMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCT LAARVDSFHESTEGKVGYELKDEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYR KMKERLGLTEIRKQANRMSFGEIEEDAYQEDLGFSLGHLGKSGSGRVRQTQVNEATKARI SKTLQRTLQKQSVVYGGKSTIRDRSSGTASSVAFTPLQGLEIVNPQAAEKKVAEANQKYF SSMAEFLKVKGEKSGLMST
Structure Information
PDB ID3JCR, 2OZB, 3SIU
Quaternary structureNA
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsNA
Connections to Disease
OMIM ID
Function 1
Function descriptioncomponent of the spliceosome
References for function11867543 28781166
E.C. numberNA
Location of functional site(s)NA
Cellular location of functioncytoplasm, spliceosome
CommentsNA
Function 2
Function descriptionbinds Ndc80/HEC1, without it see Morphologically irregular spindles; defective chromosome congression at metaphase
References for function30475206 15142036
E.C. numberNA
Location of functional site(s)NA
Cellular location of functionmitotic spindle
CommentsNA