| General Information |
| MoonProt ID | 531 |
| First appeared in release | 4.0 |
| Name(s) | Iron-regulated elongation factor tu |
| UniProt ID | P9WNN1 |
| GO terms | "GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0035375 zymogen binding
GO:0046872 metal ion binding
GO:0001666 response to hypoxia
GO:0006412 translation
GO:0006414 translational elongation
GO:0010039 response to iron ion
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall" |
| Organisms for which functions have been demonstrated | Mycobacterium tuberculosis |
| Sequence length | 396 |
| FASTA sequence | >sp|P9WNN1|EFTU_MYCTU Elongation factor Tu OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=tuf PE=1 SV=1 MAKAKFQRTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPDLNETKAFDQIDNAPEERQRGITINIAHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADAVDDEELLELVEMEVRELLAAQEFDEDAPVVRVSALKALEGDAKWVASVEELMNAVDESIPDPVRETDKPFLMPVEDVFTITGRGTVVTGRVERGVINVNEEVEIVGIRPSTTKTTVTGVEMFRKLLDQGQAGDNVGLLLRGVKREDVERGQVVTKPGTTTPHTEFEGQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTNISVKLIQPVAMDEGLRFAIREGGRTVGAGRVTKIIK |
| Structure Information |
| PDB ID | 7VMX, 7VOK |
| Quaternary structure | monomer |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in Disprot |
| Predicted Disorder Regions | Predicted disorder at amino acid residues 1-9, 49-54, 291-313, and 390-396 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. |
| References for function | Boradia, V., Malhotra, H., Thakkar, J. et al. Mycobacterium tuberculosis acquires iron by cell-surface sequestration and internalization of human holo-transferrin. Nat Commun 5, 4730 (2014). https://doi.org/10.1038/ncomms5730 |
| E.C. number | 3.6.5.3 |
| Location of functional site(s) | |
| Cellular location of function | cytosol |
| Comments | |
| Function 2 |
| Function description | binds transferrin from host |
| References for function | Boradia, V., Malhotra, H., Thakkar, J. et al. Mycobacterium tuberculosis acquires iron by cell-surface sequestration and internalization of human holo-transferrin. Nat Commun 5, 4730 (2014). https://doi.org/10.1038/ncomms5730 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |