| General Information |
| MoonProt ID | 537 |
| First appeared in release | 4.0 |
| Name(s) | Glyceraldehyde-3-phosphate dehydrogenase |
| UniProt ID | Q602B4 |
| GO terms | GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0006006 glucose metabolic process |
| Organisms for which functions have been demonstrated | Mesomycoplasma (Mycoplasma) hyopneumoniae |
| Sequence length | 336.0 |
| FASTA sequence | >tr|Q602B4|Q602B4_MESH2 Glyceraldehyde-3-phosphate dehydrogenase OS=Mesomycoplasma hyopneumoniae (strain 232) OX=295358 GN=gap PE=3 SV=1 MKKIAINGFGRIGRLALRRLFEVNDENLQVVAINDLTDASVLAHLFKYDSAHGKFNGEVEVLKDNGKNYLKIKGQKILVLSERDPKSLPWGQLGIDLVVECTGFFASKSGASQHLEAGAKKVIISAPAGNDVKTIVYNVNCDTITEDDRILSSASCTTNALAPLVNALDKEFGINHGFMTTIHAYTADQRLQDAPHGDLRRARAAGVNLVPSSTGAAKAIGLVVPSLTGKLDGIAIRVPVITGSFVDLSVELKSNPSIEEINQKMREYANESFAYCDEPIVSSDIIGDRHGSIFDATLTKYIEANGKKLYKLYTWYDNEYSFVSQFVRVIRYFVQK |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in Disprot |
| Predicted Disorder Regions | Disorder predicted from amino acid residues 1-3 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, glyceraldehyde 3-phosphate dehydrogenase, catalyzes the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate to 1,3-bisphosphate coupled with reduction of NAD+ to NADH |
| References for function | Wang J, Li S, Chen J, Gan L, Wang J, Xiong Q, Feng Z, Li Q, Deng Z, Yuan X, Yu Y. Hijacking of Host Plasminogen by Mesomycoplasma (Mycoplasma) hyopneumoniae via GAPDH: an Important Virulence Mechanism To Promote Adhesion and Extracellular Matrix Degradation. Microbiol Spectr. 2023 Jun 15;11(3):e0021823. doi: 10.1128/spectrum.00218-23. Epub 2023 May 18. PMID: 37199643; PMCID: PMC10269845. |
| E.C. number | 1.2.1 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds to plasminogen |
| References for function | Wang J, Li S, Chen J, Gan L, Wang J, Xiong Q, Feng Z, Li Q, Deng Z, Yuan X, Yu Y. Hijacking of Host Plasminogen by Mesomycoplasma (Mycoplasma) hyopneumoniae via GAPDH: an Important Virulence Mechanism To Promote Adhesion and Extracellular Matrix Degradation. Microbiol Spectr. 2023 Jun 15;11(3):e0021823. doi: 10.1128/spectrum.00218-23. Epub 2023 May 18. PMID: 37199643; PMCID: PMC10269845. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |