| General Information |
| MoonProt ID | 570 |
| First appeared in release | 4.0 |
| Name(s) | Glutathione S-transferase E14 |
| UniProt ID | Q7JYX0 |
| GO terms | GO:0003824 catalytic activity
GO:0004364 glutathione transferase activity
GO:0004769 steroid Delta-isomerase activity
GO:0016740 transferase activity
GO:0006629 lipid metabolic process
GO:0006694 steroid biosynthetic process
GO:0006749 glutathione metabolic process
GO:0009636 response to toxic substance
GO:0042632 cholesterol homeostasis
GO:0045456 ecdysteroid biosynthetic process
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Drosophila melanogaster (Fruit fly) |
| Sequence length | 232 |
| FASTA sequence | >sp|Q7JYX0|GSTEE_DROME Glutathione S-transferase E14 OS=Drosophila melanogaster OX=7227 GN=GstE14 PE=1 SV=1
MSQPKPILYYDERSPPVRSCLMLIKLLDIDVELRFVNLFKGEQFQKDFLALNPQHSVPTL
VHGDLVLTDSHAILIHLAEKFDEGGSLWPQEHAERMKVLNLLLFECSFLFRRDSDFMSAT
VRQGFANVDVAHHERKLTEAYIIMERYLENSDFMAGPQLTLADLSIVTTLSTVNLMFPLS
QFPRLRRWFTAMQQLDAYEANCSGLEKLRQTMESVGSFQFPSSSAVVTEKVE |
| Structure Information |
| PDB ID | 6KEL |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | not in DisProt |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-8), and C terminus (aa 226-232) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, glutathione S-transferase |
| References for function | "Škerlová, J., Lindström, H., Gonis, E., Sjödin, B., Neiers, F., Stenmark, P., et al.
(2020). Structure and Steroid Isomerase Activity of Drosophila Glutathione
Transferase E14 Essential for Ecdysteroid Biosynthesis. FEBS Lett. 594 (7),
1187–1195. doi:10.1002/1873-3468.13718" |
| E.C. number | EC:2.5.1.18 |
| Location of functional site(s) | |
| Cellular location of function | cytosol |
| Comments | |
| Function 2 |
| Function description | enzyme, steroid isomerase |
| References for function | "Škerlová, J., Lindström, H., Gonis, E., Sjödin, B., Neiers, F., Stenmark, P., et al.
(2020). Structure and Steroid Isomerase Activity of Drosophila Glutathione
Transferase E14 Essential for Ecdysteroid Biosynthesis. FEBS Lett. 594 (7),
1187–1195. doi:10.1002/1873-3468.13718" |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytosol |
| Comments | |