| General Information |
| MoonProt ID | 60 |
| First appeared in release | 1.0 |
| Name(s) | GAPDH
GapA isoform
Glyceraldehyde 3-phosphate dehydrogenase
Glyceraldehyde-3-phosphate dehydrogenase, type I
Gene Name: gap2
|
| UniProt ID | Q81X74 (Q81X74_BACAN), Unreviewed |
| GO terms | GO:0006006 glucose metabolic process
GO:0055114 oxidation-reduction process
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding |
| Organisms for which functions have been demonstrated | Bacillus anthracis |
| Sequence length | 334 |
| FASTA sequence | >gi|49181902|gb|AAT57278.1| glyceraldehyde 3-phosphate dehydrogenase [Bacillus anthracis str. Sterne]
MTKIGINGFGRIGRNVFRAALNNSEVEVVAINDLTDAKTLAHLLKYDTVHGTLNAEVSANENSIVVNGKEIKVIAERDPAQLPWSDYGVEVVVESTGRFTKKSDAEKHLGGSVKKVIISAPASDEDITVVMGVNHEQYDAANHNVVSNASCTTNCLAPFAKVLNEKFGVKRGMMTTIHSYTNDQQILDLPHKDLRRARAAAENMIPTSTGAAKAVALVLPELKGKLNGGAVRVPTANVSLVDLVVELDKEVTVEEVNAAFKAAAEGELKGILGYSEEPLVSIDYNGCTASSTIDALSTMVMEGNMVKVLSWYDNETGYSNRVVDLAAYMTSKGL |
| Structure Information |
| PDB ID | closest is Geobacillus at 79% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 332-334 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | glyceraldehyde 3-phosphate dehydrogenase, enzyme
catalyzes the oxidative phosphorylation of D-glyceraldehyde-
3-phosphate (G-3-P) to 1,3-diphosphoglycerate in the presence of
NAD+/NADP+ and inorganic phosphate (Pi) |
| References for function | Matta SK, Agarwal S, Bhatnagar R. Surface localized and extracellular Glyceraldehyde-3-phosphate dehydrogenase of Bacillus anthracis is a plasminogen binding protein. Biochim Biophys Acta. 2010 Nov;1804(11):2111-20. doi: 10.1016/j.bbapap.2010.08.004. Epub 2010 Aug 18.
PMID: 20727989 |
| E.C. number | 1.2.1.12 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding |
| References for function | Matta SK, Agarwal S, Bhatnagar R. Surface localized and extracellular Glyceraldehyde-3-phosphate dehydrogenase of Bacillus anthracis is a plasminogen binding protein. Biochim Biophys Acta. 2010 Nov;1804(11):2111-20. doi: 10.1016/j.bbapap.2010.08.004. Epub 2010 Aug 18.
PMID: 20727989 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |