General Information |
MoonProt ID | 60 |
First appeared in release | 1.0 |
Name(s) | GAPDH
GapA isoform
Glyceraldehyde 3-phosphate dehydrogenase
Glyceraldehyde-3-phosphate dehydrogenase, type I
Gene Name: gap2
|
UniProt ID | Q81X74 (Q81X74_BACAN), Unreviewed |
GO terms | GO:0006006 glucose metabolic process
GO:0055114 oxidation-reduction process
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding |
Organisms for which functions have been demonstrated | Bacillus anthracis |
Sequence length | 334 |
FASTA sequence | >gi|49181902|gb|AAT57278.1| glyceraldehyde 3-phosphate dehydrogenase [Bacillus anthracis str. Sterne]
MTKIGINGFGRIGRNVFRAALNNSEVEVVAINDLTDAKTLAHLLKYDTVHGTLNAEVSANENSIVVNGKEIKVIAERDPAQLPWSDYGVEVVVESTGRFTKKSDAEKHLGGSVKKVIISAPASDEDITVVMGVNHEQYDAANHNVVSNASCTTNCLAPFAKVLNEKFGVKRGMMTTIHSYTNDQQILDLPHKDLRRARAAAENMIPTSTGAAKAVALVLPELKGKLNGGAVRVPTANVSLVDLVVELDKEVTVEEVNAAFKAAAEGELKGILGYSEEPLVSIDYNGCTASSTIDALSTMVMEGNMVKVLSWYDNETGYSNRVVDLAAYMTSKGL |
Structure Information |
PDB ID | closest is Geobacillus at 79% amino acid sequence identity |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 332-334 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | glyceraldehyde 3-phosphate dehydrogenase, enzyme
catalyzes the oxidative phosphorylation of D-glyceraldehyde-
3-phosphate (G-3-P) to 1,3-diphosphoglycerate in the presence of
NAD+/NADP+ and inorganic phosphate (Pi) |
References for function | Matta SK, Agarwal S, Bhatnagar R. Surface localized and extracellular Glyceraldehyde-3-phosphate dehydrogenase of Bacillus anthracis is a plasminogen binding protein. Biochim Biophys Acta. 2010 Nov;1804(11):2111-20. doi: 10.1016/j.bbapap.2010.08.004. Epub 2010 Aug 18.
PMID: 20727989 |
E.C. number | 1.2.1.12 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | plasminogen binding |
References for function | Matta SK, Agarwal S, Bhatnagar R. Surface localized and extracellular Glyceraldehyde-3-phosphate dehydrogenase of Bacillus anthracis is a plasminogen binding protein. Biochim Biophys Acta. 2010 Nov;1804(11):2111-20. doi: 10.1016/j.bbapap.2010.08.004. Epub 2010 Aug 18.
PMID: 20727989 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cell surface |
Comments | |