| General Information |
| MoonProt ID | 68 |
| First appeared in release | 1.0 |
| Name(s) | Hsp60
GroEL1
heat shock protein 60
(not GroEL2 or GroEL3)
60 kDa chaperonin
GroEL protein
Protein Cpn60
Gene Name: groL
|
| UniProt ID | P31681 (CH60_CHLPN), Reviewed |
| GO terms | GO:0006457 protein folding
GO:0006950 response to stress
GO:0042026 protein refolding
GO:0044267 cellular protein metabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Chlamydiae pneumoniae (can cause pneumonia and other diseases) |
| Sequence length | 544 |
| FASTA sequence | >gi|33235978|gb|AAP98068.1| GroEL [Chlamydophila pneumoniae TW-183]
MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY |
| Structure Information |
| PDB ID | closest is Chlorobaculum at 66% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-11,354-359, 529-544 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | chaperonin, assist in the correct folding of new or unfolded proteins under both normal and stress conditions |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binding to cell surface and activates pathways |
| References for function | Wuppermann FN, M?lleken K, Julien M, Jantos CA, Hegemann JH. Chlamydia pneumoniae GroEL1 protein is cell surface associated and required for infection of HEp-2 cells. J Bacteriol. 2008 May;190(10):3757-67. doi: 10.1128/JB.01638-07. Epub 2008 Feb 29.
PMID: 18310329 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |