| General Information |
| MoonProt ID | 7 |
| First appeared in release | 1.0 |
| Name(s) | Hsp60
60 kDa heat shock protein, mitochondrial
Hsp60 kDa chaperonin
Chaperonin 60
CPN60
Heat shock protein 60
HSP-60
HuCHA60
Mitochondrial matrix protein P1
P60 lymphocyte protein
Gene Name: HSPD1
|
| UniProt ID | P10809 (CH60_HUMAN), Reviewed |
| GO terms | GO:0002368 B cell cytokine production
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002842 positive regulation of T cell mediated immune response to tumor cell
GO:0006200 ATP catabolic process
GO:0006457 protein folding
GO:0006458 'de novo' protein folding
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986 response to unfolded protein
GO:0008219 cell death
GO:0019048 modulation by virus of host morphology or physiology
GO:0032727 positive regulation of interferon-alpha production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0042026 protein refolding
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0043032 positive regulation of macrophage activation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0044267 cellular protein metabolic process
GO:0048291 isotype switching to IgG isotypes
GO:0050821 protein stabilization
GO:0050870 positive regulation of T cell activation
GO:0051131 chaperone-mediated protein complex assembly
GO:0051604 protein maturation
GO:0000166 nucleotide binding
GO:0001530 lipopolysaccharide binding
GO:0002039 p53 binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0009986 cell surface
GO:0030135 coated vesicle
GO:0030141 secretory granule
GO:0043231 intracellular membrane-bounded organelle
GO:0046696 lipopolysaccharide receptor complex
colocalizes_with GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex
|
| Organisms for which functions have been demonstrated | Homo sapiens and rat - (human, a mammal OMIM number 118190 612233 leukodystrophy, hypomyelinating, 4; 605280 Spastic paraplegia 13, autosomal dominant |
| Sequence length | |
| FASTA sequence | >gi|129379|sp|P10809.2|CH60_HUMAN RecName: Full=60 kDa heat shock protein, mitochondrial; AltName: Full=60 kDa chaperonin; AltName: Full=Chaperonin 60; Short=CPN60; AltName: Full=Heat shock protein 60; Short=HSP-60; Short=Hsp60; AltName: Full=HuCHA60; AltName: Full=Mitochondrial matrix protein P1; AltName: Full=P60 lymphocyte protein; Flags: Precursor
MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF |
| Structure Information |
| PDB ID | 6MRC_A |
| Quaternary structure | |
| SCOP | GroEs-like |
| CATH | 1.10.560.10, 3.30.260.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-16,105-109,377-388, 554-573 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Hsp60
mitochondrial protein import, facilitate correct folding, promote refolding, prevent misfolding of proteins
|
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | mitochondrial matrix |
| Comments | |
| Function 2 |
| Function description | receptor for HDL
affinity for apolipoprotein apoA-II |
| References for function | Bocharov AV, Vishnyakova TG, Baranova IN, Remaley AT, Patterson AP, Eggerman TL. Heat shock protein 60 is a high-affinity high-density lipoprotein binding protein. Biochem Biophys Res Commun. 2000 Oct 14. PMID: 11027668 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |