General Information |
MoonProt ID | 70 |
First appeared in release | 1.0 |
Name(s) | Hsp60
60 kDa chaperonin
GroEL protein
Cpn60
Gene Name: groL
|
UniProt ID | Q5X762 (CH60_LEGPA), Reviewed |
GO terms | GO:0006457 protein folding
GO:0042026 protein refolding
GO:0044267 cellular protein metabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
GO:0005737 cytoplasm |
Organisms for which functions have been demonstrated | Legionella pneumophila (causes Legionnaires' disease) |
Sequence length | 548 |
FASTA sequence | >sp|Q5X762|CH60_LEGPA 60 kDa chaperonin OS=Legionella pneumophila (strain Paris) GN=groL PE=3 SV=1
MAKELRFGDDARLQMLAGVNALADAVQVTMGPRGRNVVLEKSYGAPTVTKDGVSVAKEIEFEHRFMNMGAQMVKEVASKTSDTAGDGTTTATVLARSILVEGHKAVAAGMNPMDLKRGIDKAVLAVTKKLQAMSKPCKDSKAIAQVGTISANSDEAIGAIIAEAMEKVGKEGVITVEDGNGLENELSVVEGMQFDRGYISPYFINNQQNMSCELEHPFILLVDKKVSSIREMLSVLEGVAKSGRPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIAILTKGQVISEEIGKSLEGATLEDLGSAKRIVVTKENTTIIDGEGKATEINARIAQIRAQMEETTSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALIRAQKALDSLKGDNDDQNMGINILRRAIESPMRQIVTNAGYEASVVVNKVAEHKDNYGFNAATGEYGDMVEMGILDPTKVTRMALQNAASVASLMLTTECMVADLPKKEEGVGAGDMGGMGGMGGMGGMM |
Structure Information |
PDB ID | closest is E. coli at 76% amino acid sequence identity |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-10, 82-83, 352-357, 526-548 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | chaperone - Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides |
References for function | |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | adhesin |
References for function | Gardu?o RA, Gardu?o E, Hoffman PS. Surface-associated hsp60 chaperonin of Legionella pneumophila mediates invasion in a HeLa cell model. Infect Immun. 1998 Oct;66(10):4602-10 PMID: 9746556 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cell surface |
Comments | |