| General Information |
| MoonProt ID | 706 |
| First appeared in release | 3.0 |
| Name(s) | Glutathione reductase |
| UniProt ID | Q59NQ5 |
| GO terms | GO:0004362 glutathione-disulfide reductase activity
GO:0045454 cell redox homeostasis
GO:0009405 pathogenesis
GO:0034599 cellular response to oxidative stress
GO:0005829 cytosol
GO:0050660 flavin adenine dinucleotide binding
GO:0005739 mitochondrion
GO:0006749 glutathione metabolic process
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050661 NADP binding
GO:0055114 oxidation-reduction process
GO:0016491 oxidoreductase activity
GO:0005737 cytoplasm
GO:0000166 nucleotide binding
GO:0098869 cellular oxidant detoxification |
| Organisms for which functions have been demonstrated | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| Sequence length | 516 amino acids |
| FASTA sequence | >tr|Q59NQ5|Q59NQ5_CANAL Glutathione reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=GLR1 PE=3 SV=1
MFTNSIISKSTTRLTQLSRQLSTTTMAPTSTKNSIKHFDYLVIGGGSGGVASARRAAKYGAKVLLIESNFKKFGGTCVNVGCVPKKVMWYTADLAHKKHDLYAYGLDKEPDSIKYGDFDWAKLKHKRDAYVTRLNGIYENNLKREKVDYAYGFAKFINSEGEVEVTLSGDQELPFLDEGKTYKKGEKLVFSADKTLIATGGTAIVPPSVPGAELGTTSDGFFALEKQPKKVAIVGAGYIGVELSGVFSSLGSETHFFIRGDTVLRSFDEVIQNTVTDYYIDNLGINIHKQSTITKIEGSKDGKKVVHLKDGTSVEVDELIWTVGRKSLIDIGLDKVDVKINDKQQIVADEYQVTNNPKIFSLGDVVGKVELTPVAIAAGRRLSNRLFGGPEFAKDKLDYNNIPSVIFSHPEAGSIGLSTKEAIEKYGEENLKIYQSKFTAMYYAMMDDQKDKSPTVYKIICAGPEEKVVGLHIVGDSSAEILQGFGVAIKMGATKKDFDNCVAIHPTSAEELVTMT |
| Structure Information |
| PDB ID | 2HQM |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-8), middle region (aa 23), and C terminus (aa 511-516) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Reductase Activity |
| References for function | 10844651 |
| E.C. number | 1.8.1.7 |
| Location of functional site(s) | NA |
| Cellular location of function | cytoplasm |
| Comments | involved in Redox Homeostasis |
| Function 2 |
| Function description | Binding to plasma proteins |
| References for function | 29223801 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | cell surface |
| Comments | common function found in several Candida species |