| General Information |
| MoonProt ID | 74 |
| First appeared in release | 1.0 |
| Name(s) | Hsp60
GroEL
60 kDa chaperonin
Protein Cpn60
Gene Name: groL
|
| UniProt ID | F7SCR2 (F7SCR2_LACJH) |
| GO terms | GO:0006457 protein folding
GO:0042026 protein refolding
GO:0044267 cellular protein metabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Lactobacillus johnsonii La1 (NCC 533) (Gram positive bacterium) |
| Sequence length | 543 |
| FASTA sequence | >gi|45645206|sp|Q9KJ23.2|CH60_LACJO RecName: Full=60 kDa chaperonin; AltName: Full=GroEL protein; AltName: Full=Protein Cpn60
MAKEIKFSENARHSLLKGVDKLADTVKTTLGPKGRNVVLEKSYGAPDITNDGVTIAKSIELENHFENMGAKLVSEAAQKTNDIAGDGTTTATVLTQAIVREGMKNVTAGANPVGIRRGIETATKAAVDELHKISHKVSTKDEIAQVASVSSASTEVGNLIADAMEKVGHDGVITIEESKGIDTELSVVEGMQFDRGYLSQYMVTDNDKMEADLDNPYILITDKKISNIQDILPLLQEIVQQGKSLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVISSDLGLELKDTKIDQLGKAGKVTVTKDSTTIVEGAGSKEAIAERVDQIKKQIADTTSDFDREKLQERLAKLAGGVAVIKVGAATETELKERKYRIEDALNATRAAVEEGYVAGGGTALVDVMKSIQGTVKGDSEDAETGVKIVMKALGAPVRQIAENAGKDGAVILDHLEHEDPEVGYNAATNKWENMVKAGIIDPTKVTRSALQNAASIAALLLTTEAVVADAPEDDKNQAPAAPNPGMGMGM |
| Structure Information |
| PDB ID | closest is Thermus at 60% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Hsp60, GroEL, Prevents misfolding of proteins, promotes the refolding and correct assembly of unfolded proteins |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | adhesin
binds to mucins and epithelial cells |
| References for function | Bergonzelli GE, Granato D, Pridmore RD, MarvinGuy LF, Donnicola D, Corth?syTheulaz IE. GroEL of Lactobacillus johnsonii La1 (NCC 533) is cell surface associated: potential role in interactions with the host and the gastric pathogen Helicobacter pylori. Infect Immun. 2006 Jan;74(1):425-34.
PMID: 16368998 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |