| General Information |
| MoonProt ID | 8 |
| First appeared in release | 1.0 |
| Name(s) | GroEL
60 kDa chaperonin
Protein Cpn60
Gene Name:groL
|
| UniProt ID | O66198 (CH60_ENTAK), Reviewed |
| GO terms | GO:0006457 protein folding
GO:0042026 protein refolding
GO:0044267 cellular protein metabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Listeria monocytogenes (Gram positive bacterium, causes listeriosis, septicemia, meningitis) |
| Sequence length | 548 |
| FASTA sequence | >sp|O66198|CH60_ENTAK 60 kDa chaperonin OS=Enterobacter aerogenes (strain ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006) GN=groL PE=3 SV=2
MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVVAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLEDELDVVEGMQFDRGYLSPYFINKPDTGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLVIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRKQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVDDALHATRAAVEEGVVAGGGVALVRVAAKIAGLTGQNEDQNVGIKVALRAMEAPLRQIVSNAGEEPSVVANNVKAGDGNYGYNAATEEYGNMIDFGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKGDAPDLGAAGGMGGMGGMGGMM
|
| Structure Information |
| PDB ID | Closest homologue is 3U39_A with 66.11% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-11,82-85,354-360, 528-548 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | protein chaperone,
prevents proteins from misfolding, promotes correct refolding and assembly of polypeptides |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | toxin, paralyzes cockroaches
(produced by bacterium that is an endosymbiont of antlions, which are larvae of Myrmeleon bore) |
| References for function | Yoshida N, Oeda K, Watanabe E, Mikami T, Fukita Y, Nishimura K, Komai K, Matsuda K. Protein function. Chaperonin turned insect toxin. Nature. 2001 May 3;;411(6833):44. PMID: 11333970 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | secreted |
| Comments | |