| General Information |
| MoonProt ID | 85 |
| First appeared in release | 1.0 |
| Name(s) | Phosphoglycerate kinase
Gene Name: pgk
|
| UniProt ID | Q8DXT0 |
| GO terms | GO:0006096 glycolysis
GO:0016310 phosphorylation
GO:0000166 nucleotide binding
GO:0004618 phosphoglycerate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Streptococcus agalactiae (GBS = group B Streptococcus, strain NCS13) (Gram positive bacterium) |
| Sequence length | 398 aa |
| FASTA sequence | >sp|Q8DXT0|PGK_STRA5 Phosphoglycerate kinase OS=Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) GN=pgk PE=3 SV=1
MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEEADKEGKSLAPVAADLAAKLGQDVVFPGVTRGAKLEEAINALEDGQVLLVENTRFEDVDGKKESKNDEELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKDLLEKSNGKLILPVDSKEANAFAGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
|
| Structure Information |
| PDB ID | closest is Streptococcus pneumonia with 99% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-2, 66-69, 125-129, 397-398 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Phosphoglycerate kinase
ADP + 1,3-bisphosphoglycerate => ATP + 3-phosphoglycerate
Carbohydrate degradation, glycolysis |
| References for function | |
| E.C. number | 2.7.2.3 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding |
| References for function | Boone TJ, Burnham CA, Tyrrell GJ. Binding of group B streptococcal phosphoglycerate kinase to plasminogen and actin.Microb Pathog. 2011 Oct;51(4):255-61. doi: 10.1016/j.micpath.2011.06.005. Epub 2011 Jun 28. PMID: 21729749
|
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |