| General Information |
| MoonProt ID | 93 |
| First appeared in release | 1.0 |
| Name(s) | Pyruvate kinase
PK
Gene Name: pyk
|
| UniProt ID | Q07637 (KPYK_LACLA), Reviewed |
| GO terms | GO:0006096 glycolysis
GO:0008152 metabolic process
GO:0016310 phosphorylation
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding |
| Organisms for which functions have been demonstrated | Lactococcus lactis IL1403 (Gram positive bacterium) |
| Sequence length | 502 |
| FASTA sequence | >sp|Q07637|KPYK_LACLA Pyruvate kinase OS=Lactococcus lactis subsp. lactis (strain IL1403) GN=pyk PE=3 SV=2
MNKRVKIVSTLGPAVEIRGGKKFGESGYWGESLDVEASAKNIAALIEEGANVFRFNFSHGDHPEQGARMATVHRAEEIAGHKVGFLLDTKGPEMRTELFADGADAISVVTGDKFRVATKQGLKSTPELIALNVAGGLDIFDDVEIGQTILIDDGKLGLSLTGKDAATREFEVEAQNDGVIGKQKGVNIPNTKIPFPALAERDDADIRFGLSQPGGINFIAISFVRTANDVKEVRRICEETGNPHVQLLAKIENQQGIENLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKLIISKVNKAGKIVVTATNMLESMTYNPRATRSEISDVFNAVIDGTDATMLSGESANGKYPRESVRTMATVNKNAQTMLKEYGRLHPERYDKSTVTEVVAASVKNAAEAMDIKLIVALTESGNTARLISKHRPNADILAITFDEKVERGLMINWGVIPTMTEKPSSTDDMFEVAEKVALASGLVESGDNIIIVAGVPVGTGRTNTMRIRTVK
|
| Structure Information |
| PDB ID | closest is Geobacillus with 44% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3, 29-31, 376-383 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Pyruvate kinase, enzyme
ADP + phosphoenolpyruvate => ATP + pyruvate
Carbohydrate degradation, glycolysis |
| References for function | |
| E.C. number | 2.7.1.40 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiae |
| References for function | Katakura Y, Sano R, Hashimoto T, Ninomiya K, Shioya S. 2010. Lactic acid bacteria display on the cell surface cytosolic proteins that recognize yeast mannan. Appl Microbiol Biotechnol. 2010 Mar;86(1):319-26. doi: 10.1007/s00253-009-2295-y. Epub 2009 Nov 7.
PMID: 19898842 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |